منابع مشابه
Reduced sodium concentration and increased sodium-potassium pump activity of erythrocytes in human hypertension.
Erythrocyte Nai, Nai/Ki and ouabain-sensitive and ouabain-insensitive 86Rb uptake (K transport) were measured in whole blood of 16 normotensive and 19 hypertensive white male subjects, within seconds or minutes after withdrawal of blood. Erythrocyte Nai and Nai/Ki were reduced (p less than 0.05), and ouabain-sensitive 86Rb uptake was increased (p less than 0.01) in hypertensive subjects. In a s...
متن کاملPlakoglobin and Adipogenesis in ARVC
Too much plakoglobin protein in the nuclei of heart cells turns them into fat cells and causes arrhythmia, report Lombardi et al. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is most commonly caused by mutations to genes encoding desmosome proteins, such as plakoglobin (PG). ARVC-causing mutations in PG are known to release the protein from intercellular junctions and drive its accumu...
متن کاملVoltage-Gated Sodium Channels Modulation by Bothutous Schach Scorpion Venom
Buthotus schach is one of the dangers scorpion in Iran that belong to the Buthidae family. Toxins are existing in venom scorpion, modulate the ion channels by blocking or opening the pore of the channel or by altering the voltage gating and useful as pharmacological tools. In the present study, we investigated the effect of venom and its obtained fractions by gel filtrations on electrophysiolog...
متن کاملReduced BOLD response in mice lacking nociceptor specific sodium channels (Nav1.7) indicates altered pain processing
INTRODUCTION Functional magnetic resonance imaging (fMRI) has been widely used to study brain function in humans and in animals, especially in rats. In view of the increasing number of transgenic mouse lines used in research, we developed a robust stimulation paradigm to study pain processing in mice [1]. Studies in rats using electrical forepaw stimulation have revealed that noxious-evoked act...
متن کاملEffects of i.v. anaesthetics on human brain sodium channels.
The well established correlation between the potency and lipid solubility of anaesthetic compounds (Meyer-Overton correlation) has pointed to excitable membranes and membrane ion channels as possible molecular sites for anaesthetic actions, and it is now accepted widely that anaesthetics act predominantly through interactions with nerve cell membranes [46]. Many suggestions concerning detailed ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Heart Rhythm
سال: 2013
ISSN: 1547-5271
DOI: 10.1016/j.hrthm.2012.12.019